Incremental backups on deduplication disk storage?

Hello,

I'm in the middle of setting up backup jobs for our new Backup Exec Appliance 3600. As it's my first time using a dedupe disk store I was wondering...

Does it make sense to create incremental backup jobs on a dedupe disk store?

(Or shall I only use full backup jobs... because as I understand it, backup size and time should be the same, right?)

Background info...
We want to backup two ESX (VMware) hosts.
On each hosts are 4 VMs with Windows Server 2008 R2.
Granular file restore should be possible from all VMs.

Thanks for your answer,

Florian